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Nature Research Journals

Deep learning sequence-based ab initio prediction of variant effects on expre...

Deep learning sequence-based ab initio prediction of variant effects on expression and disease risk

Deep learning sequence-based ab initio prediction of variant effects on expression and disease risk, Published online: 16 July 2018; doi:10.1038/s41588-018-0160-6

ExPecto is a deep learning?based framework that can predict the tissue-specific transcriptional effects of mutations on the basis of DNA sequence alone. ExPecto can prioritize causal variants from GWAS loci and be used to predict the disease risk of a variant.
16 Jul 2018 at 12:00am

Common variation near IRF6 is associated with IFN-?-induced liver injury in m...

Common variation near IRF6 is associated with IFN-?-induced liver injury in multiple sclerosis

Common variation near <i>IRF6</i> is associated with IFN-?-induced liver injury in multiple sclerosis, Published online: 16 July 2018; doi:10.1038/s41588-018-0168-y

A genome-wide study identifies common variation near IRF6 associated with liver injury induced by IFN-? in individuals treated for multiple sclerosis. The risk locus is associated with differential expression of IRF6 and may help guide safer use of this biologic.
16 Jul 2018 at 12:00am

Genome-wide association and HLA fine-mapping studies identify risk loci and g...

Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis

Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis, Published online: 16 July 2018; doi:10.1038/s41588-018-0157-1

Genome-wide association analyses identify new risk loci for allergic rhinitis and for sensitization to inhalant allergens. The associated regions implicate immune-related pathways, including innate and adaptive IgE-related mechanisms.
16 Jul 2018 at 12:00am

Fetal gene therapy for neurodegenerative disease of infants

Fetal gene therapy for neurodegenerative disease of infants

Fetal gene therapy for neurodegenerative disease of infants, Published online: 16 July 2018; doi:10.1038/s41591-018-0106-7

In utero GBA gene therapy extends lifespan and provides long-lasting phenotypic amelioration in a mouse model of neuronopathic Gaucher disease. Fetal ultrasound-guided in utero gene vector delivery is also achieved in the non-human primate brain.
16 Jul 2018 at 12:00am

Predicting progression to AML

Predicting progression to AML

Predicting progression to AML, Published online: 09 July 2018; doi:10.1038/s41591-018-0114-7

The number, identity, and burden of mutations in clonal hematopoiesis are associated with the risk and timing of progression to acute myeloid leukemia.
9 Jul 2018 at 12:00am

The maternal vaginal microbiome partially mediates the effects of prenatal st...

The maternal vaginal microbiome partially mediates the effects of prenatal stress on offspring gut and hypothalamus

The maternal vaginal microbiome partially mediates the effects of prenatal stress on offspring gut and hypothalamus, Published online: 09 July 2018; doi:10.1038/s41593-018-0182-5

Maternal stress during pregnancy is a risk factor for neurodevelopmental disorders. Jasarevic and colleagues show that the maternal vaginal microbiota partially mediates the lasting effects of prenatal stress on the gut and hypothalamus in mice.
9 Jul 2018 at 12:00am


Nature Reviews (Life Sciences) Journals


Nature Reviews (Clinical Sciences) Journals

Infant medulloblastoma ? learning new lessons from old strata

Infant medulloblastoma ? learning new lessons from old strata

Infant medulloblastoma ? learning new lessons from old strata, Published online: 20 July 2018; doi:10.1038/s41571-018-0071-6

Comprehensive molecular characterization of infant medulloblastoma has uncovered the high degree of heterogeneity of this disease. Recent results from the SJYC07 study elegantly reveal that risk stratification can be improved if DNA methylation profiling data are incorporated into clinicopathological criteria. Importantly, the delineation of disease subgroups potentially has major clinical implications.
20 Jul 2018 at 12:00am

Sodium thiosulfate halves the risk of cisplatin-induced hearing loss

Sodium thiosulfate halves the risk of cisplatin-induced hearing loss

Sodium thiosulfate halves the risk of cisplatin-induced hearing loss, Published online: 06 July 2018; doi:10.1038/s41571-018-0067-2

Sodium thiosulfate halves the risk of cisplatin-induced hearing loss
6 Jul 2018 at 12:00am

What now for embolic stroke of undetermined source?

What now for embolic stroke of undetermined source?

What now for embolic stroke of undetermined source?, Published online: 11 July 2018; doi:10.1038/s41582-018-0046-3

In a recent study, rivaroxaban was not superior to aspirin for secondary prevention of stroke and systemic emboli after an initial embolic stroke of undetermined source (ESUS) but was associated with a higher risk of bleeding. What does that mean for the concept of ESUS and for future trials?
11 Jul 2018 at 12:00am

Retinal nerve fibre layer thickness ? a biomarker of early dementia?

Retinal nerve fibre layer thickness ? a biomarker of early dementia?

Retinal nerve fibre layer thickness ? a biomarker of early dementia?, Published online: 11 July 2018; doi:10.1038/s41582-018-0044-5

Retinal nerve fibre layer thickness ? a biomarker of early dementia?
11 Jul 2018 at 12:00am

Risk of dementia after TBI ? a cause of growing concern

Risk of dementia after TBI ? a cause of growing concern

Risk of dementia after TBI ? a cause of growing concern, Published online: 10 July 2018; doi:10.1038/s41582-018-0041-8

Moderate and severe traumatic brain injuries (TBIs) have long been recognized as risk factors for dementia, but the relationship between mild TBI (mTBI) and dementia is unclear. New research demonstrates that even an mTBI without loss of consciousness is associated with a twofold increase in the risk of dementia.
10 Jul 2018 at 12:00am

Sex differences in Alzheimer disease ? the gateway to precision medicine

Sex differences in Alzheimer disease ? the gateway to precision medicine

Sex differences in Alzheimer disease ? the gateway to precision medicine, Published online: 09 July 2018; doi:10.1038/s41582-018-0032-9

In this Review, Ferretti et al. discuss the evidence for sex-related differences in Alzheimer disease symptoms, progression, risk factors and treatment, and consider how understanding sex differences is crucial in developing precision medicine.
9 Jul 2018 at 12:00am


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