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Nature: Current issue

The devastating death toll forecast for Himalayan quakes

The devastating death toll forecast for Himalayan quakes

The devastating death toll forecast for Himalayan quakes, Published online: 17 September 2018; doi:10.1038/d41586-018-06702-9

Hundreds of thousands of lives are at risk as a result of population boom in seismic zone.
17 Sep 2018 at 12:00am

Gene editing reveals the effect of thousands of variants in a key cancer gene

Gene editing reveals the effect of thousands of variants in a key cancer gene

Gene editing reveals the effect of thousands of variants in a key cancer gene, Published online: 12 September 2018; doi:10.1038/d41586-018-06022-y

Gene editing has now been used to introduce every possible single-nucleotide mutation into key protein-coding regions in the cancer-predisposition gene BRCA1, to identify the variants that are linked to cancer risk.
12 Sep 2018 at 12:00am


Scientific American: Current issue


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Nature Research Journals

Mutations in RECQL are not associated with breast cancer risk in an Australia...

Mutations in RECQL are not associated with breast cancer risk in an Australian population

Mutations in <i>RECQL</i> are not associated with breast cancer risk in an Australian population, Published online: 17 September 2018; doi:10.1038/s41588-018-0206-9

Mutations in RECQL are not associated with breast cancer risk in an Australian population
17 Sep 2018 at 12:00am

Fine-mapping and functional studies highlight potential causal variants for r...

Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes

Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes, Published online: 17 September 2018; doi:10.1038/s41588-018-0216-7

Fine-mapping and functional studies highlight potential causal risk variants for rheumatoid arthritis and type 1 diabetes, including missense variants at DNASE1L3, PTPN22, SH2B3, and TYK2, and noncoding variants at MEG3, CD28?CTLA4, and IL2RA.
17 Sep 2018 at 12:00am

Restoring wild-type-like CA1 network dynamics and behavior during adulthood i...

Restoring wild-type-like CA1 network dynamics and behavior during adulthood in a mouse model of schizophrenia

Restoring wild-type-like CA1 network dynamics and behavior during adulthood in a mouse model of schizophrenia, Published online: 17 September 2018; doi:10.1038/s41593-018-0225-y

The authors report that impaired hippocampal synchrony in a mouse model of schizophrenia is due to parvalbumin interneuron hypoexcitability. Rescuing interneuron excitability during adulthood restores wild-type-like network dynamics and behavior.
17 Sep 2018 at 12:00am

Neural implementation of Bayesian inference in a sensorimotor behavior

Neural implementation of Bayesian inference in a sensorimotor behavior

Neural implementation of Bayesian inference in a sensorimotor behavior, Published online: 17 September 2018; doi:10.1038/s41593-018-0233-y

Behavior is the result of a Bayesian computation that weights past experience and current sensory information by their reliabilities. Here single-neuron activity in eye movement cortex exemplifies how the brain implements a Bayesian computation.
17 Sep 2018 at 12:00am

Structure of the mechanosensitive OSCA channels

Structure of the mechanosensitive OSCA channels

Structure of the mechanosensitive OSCA channels, Published online: 06 September 2018; doi:10.1038/s41594-018-0117-6

Cryo-EM and electrophysiological studies of two mechanosensitive OSCA channels from Arabidopsis thaliana reveal their structural similarity to osmosensitive TMEM16 channels and suggest they are gated by force from lipid in response to osmotic stress.
6 Sep 2018 at 12:00am


Nature Reviews (Life Sciences) Journals


Nature Reviews (Clinical Sciences) Journals

Precision risk-based screening might maximize benefit and minimize harm

Precision risk-based screening might maximize benefit and minimize harm

Precision risk-based screening might maximize benefit and minimize harm, Published online: 14 September 2018; doi:10.1038/s41571-018-0093-0

Population-based mammographic screening is widely accepted as an intervention to reduce overall mortality from breast cancer, but at the cost of morbidity due to false positives and substantial overdiagnosis and overtreatment of ultra-low-risk disease, as well as personal and health-economic burdens. Recent data from a modelling study strengthen the rationale for personalized, risk-based screening approaches, now being tested in multiple clinical trials.
14 Sep 2018 at 12:00am

Alcohol and dementia ? risk or protective factor?

Alcohol and dementia ? risk or protective factor?

Alcohol and dementia ? risk or protective factor?, Published online: 13 September 2018; doi:10.1038/s41582-018-0073-0

A new publication from the Whitehall study confirms earlier findings that light to moderate alcohol drinkers have a reduced risk of dementia compared with abstainers and heavy drinkers. Importantly, the study follows a cohort from middle age, whereas most previous research on this topic has focused on older adults.
13 Sep 2018 at 12:00am

Neurofilaments as biomarkers in neurological disorders

Neurofilaments as biomarkers in neurological disorders

Neurofilaments as biomarkers in neurological disorders, Published online: 31 August 2018; doi:10.1038/s41582-018-0058-z

In this Review, Khalil et al. consider how technological advances have enabled the detection of neurofilament proteins in the blood, and discuss how these proteins consequently have the potential to be easily measured biomarkers of neuroaxonal injury in various neurological conditions.
31 Aug 2018 at 12:00am

A potential biomarker strategy to monitor treatment response in spinal muscul...

A potential biomarker strategy to monitor treatment response in spinal muscular atrophy

A potential biomarker strategy to monitor treatment response in spinal muscular atrophy, Published online: 29 August 2018; doi:10.1038/s41582-018-0068-x

A potential biomarker strategy to monitor treatment response in spinal muscular atrophy
29 Aug 2018 at 12:00am


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