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Science

Steep drop in Zika cases undermines vaccine trial
13 Sep 2018 at 5:37pm

New cancer-fighting cells enter trials
13 Sep 2018 at 5:37pm

Prioritizing population policies
13 Sep 2018 at 5:37pm

Differential IL-2 expression defines developmental fates of follicular versus...

In response to infection, naïve CD4+ T cells differentiate into two subpopulations: T follicular helper (TFH) cells, which support B cell antibody production, and non-TFH cells, which enhance innate immune cell functions. Interleukin-2 (IL-2), the major cytokine produced by naïve T cells, plays an important role in the developmental divergence of these populations. However, the relationship between IL-2 production and fate determination remains unclear. Using reporter mice, we found that differential production of IL-2 by naïve CD4+ T cells defined precursors fated for different immune functions. IL-2 producers, which were fated to become TFH cells, delivered IL-2 to nonproducers destined to become non-TFH cells. Because IL-2 production was limited to cells receiving the strongest T cell receptor (TCR) signals, a direct link between TCR-signal strength, IL-2 production, and T cell fate determination has been established.


13 Sep 2018 at 5:37pm

Arbovirus risk in Brazil
30 Aug 2018 at 5:39pm

Population health and national development
23 Aug 2018 at 5:30pm


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British Medical Journal


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Most-read BMJ articles


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