CCBAR logo

CCBAR Newsletter – March, 2014

Editors:  Natalia Gavrilova and Stacy Tessler Lindau  


NIA-Sponsored Biomarker Network Meeting
The abstract "Vaginal cytological characteristics as a biomeasure of estrogenization in a community-based population of older women" by Natalia Gavrilova, Annie Dude, Joscelyn N. Hoffmann, Martha K. McClintock, L. Philip Schumm and Stacy Tessler Lindau has been accepted for presentation at the NIA-sponsored Biomarker Network Meeting in
Boston, MA - Boston Marriott Copley Place, Wednesday April 30, 2014 (8:30 - 4:30).


Do you know what the average length of time was for the collection of medications in NSHAP?

A: The raw data from wave 1 of the NSHAP study (with timestamps available) show that the median time for the medication log was 3  minutes with an average of about 4. This time is just for the medication log and does not include the follow-up questions about hormone use, etc.
We would like to thank Kristen Wroblewski for providing an answer to this question.

News from the NEJM, Nature Journals, Science, BMJ, PNAS, Lancet and JAMA

Medicine: Adapt current tools for handling big data
by Ervin Sejdi
To speed up discoveries of disease biomarkers and treatments, we must work out a cheaper and faster way to process, store and use the huge medical data sets that are rapidly becoming available 
Human evolution: Hominin explorers were poor planners
Hominin migrations, such as those out of Africa, might have been led by individuals with low levels of foresight.A team led by Colin Wren at McGill University in Montreal, Canada, modelled the migratory behaviour of individuals, based on the complexity of their environments and
Risk factors: Depression recognized as a risk factor in ACS
by Gregory B. Lim
A scientific statement from the AHA recommends that depression be recognized as a risk factor for poor prognosis in patients with an acute coronary syndrome (ACS). The committee of experts performed a systematic review of the published literature and concluded that the preponderance of evidence
Diagnosis: High use of noninvasive imaging tests not associated with short-te...
by Bryony M. Mearns
"With health-care costs at unsustainably high levels, our team feels the urgency to explore ways in which hospitals and health-care systems can be more efficient in providing high-quality patient care," says Dr Kyan Safavi from the Yale University School of Medicine in New Haven, CT,
Matching and causal mechanisms [Sustainability Science]
by Agrawal, A.
Excitement among social scientists about the discovery of randomized controlled trials has been tempered by the recognition that experimental research and related designs may be infeasible, prohibitively expensive, or even unsuitable for an enormous range of questions of interest to social science a...
Neural mechanisms underlying indirect reciprocity [Social Sciences]
by Watanabe, T., Takezawa, M., Nakawake, Y., Kunimatsu, A., Yamasue, H., Nakamura, M., Miyashita, Y., Masuda, N.
Cooperation is a hallmark of human society. Humans often cooperate with strangers even if they will not meet each other again. This so-called indirect reciprocity enables large-scale cooperation among nonkin and can occur based on a reputation mechanism or as a succession of pay-it-forward behavior....
Contextual effect of positive intergroup contact [Social Sciences]
by Christ, O., Schmid, K., Lolliot, S., Swart, H., Stolle, D., Tausch, N., Al Ramiah, A., Wagner, U., Vertovec, S., Hewstone, M.
We assessed evidence for a contextual effect of positive intergroup contact, whereby the effect of intergroup contact between social contexts (the between-level effect) on outgroup prejudice is greater than the effect of individual-level contact within contexts (the within-level effect). Across seve...
[Focus] The A4 Study: Stopping AD Before Symptoms Begin?
by Sperling, R. A., Rentz, D. M., Johnson, K. A., Karlawish, J., Donohue, M., Salmon, D. P., Aisen, P.
A new secondary prevention trial in older people with amyloid accumulation at high risk for Alzheimer’s disease dementia should provide insights into whether anti-amyloid therapy can delay cognitive decline.
[Research Articles] Longitudinal Change in CSF Biomarkers in Autosomal-Domina...
by Fagan, A. M., Xiong, C., Jasielec, M. S., Bateman, R. J., Goate, A. M., Benzinger, T. L. S., Ghetti, B., Martins, R. N., Masters, C. L., Mayeux, R., Ringman, J. M., Rossor, M. N., Salloway, S., Schofield, P. R., Sperling, R. A., Marcus, D., Cairns, N. J., Buckles, V. D., Ladenson, J. H., Morris, J. C., Holtzman, D. M., The Dominantly Inherited Alzheimer Network
Clinicopathological evidence suggests that the pathology of Alzheimer’s disease (AD) begins many years before the appearance of cognitive symptoms. Biomarkers are required to identify affected individuals during this asymptomatic ("preclinical") stage to permit intervention with potential dise...
Caregiver Burden A Clinical Review
by Adelman RD, Tmanova LL, Delgado D, et al.
Caregiver burden may result from providing care for patients with chronic illness. It can occur in any of the 43.5 million individuals providing support to midlife and older adults. Caregiver burden is frequently overlooked by clinicians. Objectives: To outline the epidemiology of caregiver b...
Cortisol shifts financial risk preferences [Neuroscience]
by Kandasamy, N., Hardy, B., Page, L., Schaffner, M., Graggaber, J., Powlson, A. S., Fletcher, P. C., Gurnell, M., Coates, J.
Risk taking is central to human activity. Consequently, it lies at the focal point of behavioral sciences such as neuroscience, economics, and finance. Many influential models from these sciences assume that financial risk preferences form a stable trait. Is this assumption justified and, if not, wh...
Cortisol as a biomarker for depression in boys [Psychological and Cognitive S...
by Owens, M., Herbert, J., Jones, P. B., Sahakian, B. J., Wilkinson, P. O., Dunn, V. J., Croudace, T. J., Goodyer, I. M.
Major depressive disorder (MD) is a debilitating public mental health problem with severe societal and personal costs attached. Around one in six people will suffer from this complex disorder at some point in their lives, which has shown considerable etiological and clinical heterogeneity. Overall t...

Biomarkers and Aging in the News Media

Why happiness is a healthy choice
Managing emotional ups and downs and holding on to the sense of purpose and meaning, are important to physical health, experts say.
Study ties breast gene to high-risk uterine cancer
Women with a faulty breast cancer gene might face a greater chance of rare but deadly uterine tumors despite having their ovaries removed to lower their main cancer risks, doctors are reporting....
Big climate report: Warming is big risk for people
If you think of climate change as a hazard for some far-off polar bears years from now, you're mistaken. That's the message from top climate scientists gathering in Japan this week to assess the impact of global warming....
Salt makes obese teens' cells age faster, study says
Study found cells called telomeres -- which play a role in aging -- were shorter in overweight and obese teens who ate a lot of salt
Stress May Diminish a Woman's Fertility, Study Suggests
First U.S. review to show a possible link between stress and how long it takes to get pregnant
For Happy Marriage, His Personality May Be Key
Study looked at health, 'positivity' and other traits in older couples
Stress-Linked Protein May Play Role in Alzheimer's
Stress-Linked Protein May Play Role in Alzheimer's
Women Bear Brunt of Alzheimer's Disease
New report highlights gender differences in disease risk and caregiver burden.
Blood Test Might Predict Who Will Develop Alzheimer's
A blood test that can predict who is about to develop Alzheimer's or related early memory loss up to two years before the first symptoms may be in early stages of development, researchers believe.Many scientists have tried, and failed, to come up with a test that can predict Alzheimer's.
Lower IQ and poorer cardiovascular fitness in teen years increase risk of ear...
Men who at the age of 18 years have poorer cardiovascular fitness and/or a lower IQ more often suffer from dementia before the age of 60. This is shown in a recent study encompassing more than one million Swedish men.
State-of-the-state on genetic-based testing, treatment for breast cancer reve...
A review of the role that information gathered through genetic testing plays in the diagnosis and treatment of breast cancer has been conducted. The resulting paper discusses targeted therapies, new biomarkers, and the quality of commercially available testing methods.
Unconscious mind can detect a liar -- even when the conscious mind fails
When it comes to detecting deceit, your automatic associations may be more accurate than conscious thought in pegging truth-tellers and liars, according to research. The findings suggest that conscious awareness may hinder our ability to detect whether someone is lying, perhaps because we tend to seek out behaviors that are supposedly stereotypical of liars, like averted eyes or fidgeting. But those behaviors may not be all that indicative of an untrustworthy person.
Saturated fat advice 'unclear'
Swapping butter for a sunflower spread may not lower heart risk, say researchers, but experts warn against eating foods high in saturated fat.
More Body Fat Raises Ovarian Cancer Risk, Study Suggests
The more a woman weighs, the greater her risk of ovarian cancer, a new report suggests.It adds to strong suspicions that weight is somehow linked to ovarian cancer, one of the deadliest cancers and one that kills 14,000 U.S. women every year.
Eat more, die young: Why eating a diet very low in nutrients can extend lifespan
A new evolutionary theory claims that consuming a diet very low in nutrients can extend lifespan in laboratory animals, a finding which could hold clues to promoting healthier aging in humans. Scientists have known for decades that severely restricted food intake reduces the incidence of diseases of old age, such as cancer, and increases lifespan. The most widely accepted theory is that this effect evolved to improve survival during times of famine.
Healthy midlife diet may prevent dementia later
Healthy dietary choices in midlife may prevent dementia in later years, according a doctoral thesis. The results showed that those who ate the healthiest diet at the average age of 50 had an almost 90 per cent lower risk of dementia in a 14-year follow-up study than those whose diet was the least healthy. The study was the first in the world to investigate the relationship between a healthy diet as early as in midlife and the risk of developing dementia later on.
Well: Anger Can Set Off a Heart Attack
A new analysis has found that outbursts of anger can significantly increase the risk for irregular heart rhythms, angina, strokes and heart attacks.
Stress undermines empathic abilities in men but increases them in women
Stressed males tend to become more self-centered and less able to distinguish their own emotions and intentions from those of other people. For women the exact opposite is true. Stress, this problem that haunts us every day, could be undermining not only our health but also our relationships with other people, especially for men. Stressed women, however, become more 'prosocial' according to new research.
Income Gap, Meet the Longevity Gap
Two counties, separated by fortune and 350 miles, demonstrate the widening divide in life expectancy between affluent and struggling areas of the United States.
Does Self-Esteem Affect Seniors' Health?
Small study tied higher levels of stress hormone to less well-being in older adults
Wider Waistline May Mean Shorter Lifespan: Study
Evidence review suggests extra inches raise risk of dying younger, regardless of body weight
Even Slightly Higher Blood Pressure May Raise Stroke Risk: Study
Experts say the finding highlights importance of keeping blood pressure under control
Younger men receive faster care for heart attacks, angina compared with women...
In younger adults experiencing heart attacks and angina, men are more likely to receive faster care compared with women, new research shows. In the study, men received faster access to electrocardiograms (ECGs) and fibrinolysis than women, with door-to-ECG and door-to-needle times of 15 and 21 minutes and 28 and 36 minutes, respectively. The study also found that gender-related factors affected access to care for both men and women.
Colon cancer incidence rates decreasing steeply in older Americans, study shows
Colon cancer incidence rates have dropped 30 percent in the US in the last 10 years among adults 50 and older due to the widespread uptake of colonoscopy, with the largest decrease in people over age 65. Like incidence, mortality rates have also declined most rapidly within the past decade. From 2001 to 2010, rates decreased by approximately 3 percent per year in both men and women, compared with declines of approximately 2 percent per year during the 1990s.
Statin debate: A bitter pill?
Are statins a risk worth taking?
Vitamin D may boost breast cancer survival odds
Foods high in vitamin D are fatty fish and cod liver oil; fortified milks, cheeses and cereals also contain some of the vitamin
New Study Points To Health Risk Of Prolonged Sitting
Northwestern University research time has found that prolonged sitting is a health problem, all by itself.
Men: The clock on your sperm is ticking
A comprehensive study suggests children with older fathers are at a great risk for a host of psychiatric disorders.

NIH Press Releases

Researchers discover underlying genetics, marker for stroke, cardiovascular d...
NIH-funded findings point to new potential strategies for disease prevention, treatment.
Sepsis study comparing three treatment methods shows same survival rate
NIH-funded clinical trial tested specific protocols against usual high-level care
NIH urges older Americans to protect their kidneys
Statement of NIDDK Director Griffin P. Rodgers, M.D., and NIA Director Richard J. Hodes, M.D.
Students unlock the mysteries of the brain with NIH scientists
NIH celebrates Brain Awareness Week 2014.
Contacts better than permanent lenses for babies after cataract surgery
Permanent lenses lead to more repeat eye surgeries, NIH study finds.
NIH announces recruitment for clinical trial to test new tinnitus treatment d...
Multi-center trial offers hope for millions of Americans with severe tinnitus.
3-D changes in DNA may lead to a genetic form of Lou Gehrig's disease
NIH-funded scientists reveal how a genetic code variation results in devastating brain diseases.
High plasticizer levels in males linked to delayed pregnancy for female partners
NIH study of couples implicates three common phthalates in delay.
Prevalence of allergies the same, regardless of where you live
Study suggests that people prone to developing allergies are going to develop an allergy to whatever is in their environment.
Suicide in the military: Army-NIH funded study points to risk and protective ...
Largest study of mental health risk and resilience ever conducted among U.S. military personnel.

Funding Announcements

Juvenile Protective Factors and Their Effects on Aging (R03)
Expiration Date: July 17, 2016
Analysis of Genome-Wide Gene-Environment (G x E) Interactions (R21)
Funding Opportunity PAR-13-382 from the NIH Guide for Grants and Contracts. The purpose of this FOA is to provide support for research projects that involve secondary data analyses of existing genome-wide data from genome-wide association studies or other large genomic datasets for the purpose of identifying gene-environment interactions. The ultimate objective of this funding opportunity is the discovery of complex interplays of genes and environmental factors in human populations which may disclose novel genetic susceptibilities to environmental exposures or a greater understanding of the role of environmental exposures in the development, progression, and severity of complex human diseases.
NIH Support for Conferences and Scientific Meetings (Parent R13/U13)
Funding Number: PA-13-347
Expiration Date: September 8, 2016
Academic Research Enhancement Award (Parent R15)
Funding Number: PA-13-313
Expiration Date: September 8, 2016
Behavioral and Social Science Research on Understanding and Reducing Health Disparities (R21)
Funding Number: PA-13-288
Expiration Date: September 8, 2016
Mid-life Reversibility of Early-established Biobehavioral Risk Factors (R01)
Funding Opportunity RFA-AG-14-006 from the NIH Guide for Grants and Contracts. The purpose of this funding opportunity announcement (FOA) issued by the National Institute on Aging (NIA) is to solicit two-year Research Project Grant (R01) applications that propose to explore the potential for midlife plasticity of biobehavioral or psychological systems affected by early life disadvantage. In order to speed the development of novel intervention strategies, applicants are encouraged either to use existing human cohort data to identify circumstances that mitigate or exacerbate the effects of early adversity or to use human and/or animal models to test the feasibility of developing interventions aimed specifically at increasing malleability in adulthood of risk persistence mechanisms.
High Priority Behavioral and Social Research Networks (R24)
Funding Opportunity RFA-AG-14-007 from the NIH Guide for Grants and Contracts. The purpose of this funding opportunity announcement (FOA) issued by the National Institute on Aging (NIA), working in part with funds contributed by the NIH Office of Behavioral and Social Sciences Research ( ), is to provide infrastructure support for advancing development of specific emerging and high priority interdisciplinary areas of behavioral and social research of relevance to aging. The infrastructure support will facilitate research networks through meetings, conferences, small scale pilots, training, and dissemination to encourage growth and development of specified priority areas and of resources for the field at large. Projects are solicited that will develop, strengthen, and evaluate transdisciplinary approaches and methods for basic behavioral and/or social research.
Regional and International Differences in Health and Longevity at Older Ages (R01) PA-13-125
Expiration Date September 8, 2016
Obesity Policy Evaluation Research (R01) PA-13-110
Expiration Date: May 8, 2016



2014 Annual Meeting of the Population Association of America 
Marriott Copley Place, Boston, MA, May 1-3, 2014
Abstract deadline was September 27, 2013

2014 Annual Scientific Meeting of the American Geriatrics Society (AGS), May 15 - 17, 2014
Orlando, Florida
Abstract deadline was December 2, 2013 at 11:59 pm EST

The 26th REVES meeting on health expectancy
Edinburgh, UK, May 28-30, 2014
Abstract submission deadline: February 1, 2014

The 67th Annual Meeting of the Gerontological Society of America, November 5-9, 2014
Walter E. Washington Convention Center, Washington, DC
Abstract submission deadline: March 5, 2014

This Newsletter  is supported by a grant from the National Institute on Aging, National Institutes of Health (Grant No. 5 P30 AG012857)

If you would like to unsubscribe please notify us at