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CCBAR Newsletter – November-December, 2008

Editors:  Natalia Gavrilova and Stacy Tessler Lindau

CCBAR News

New CCBAR technical reports on blood spot speciemens (hemoglobin, HbA1c, CRP, EBV) are published online: http://biomarkers.uchicago.edu/ccbartechreports.html. These may be useful to other researchers seeking to collect blood spots in the population setting.  We have also posted a template technical report for studies collecting biomeasures.   Generating technical reports is greatly facilitated by starting early in the process of study protocol development.  The template can be shared with laboratory partners in developing the scope of work so as to ensure delivery of the information needed to track equipment, assays and assay characteristics, protocols, and changes in these important areas over time. The technical report is also critical for authors working with the data who will need detailed methodological information for interpretation, comparison across studies, and to accurately write methods sections of manuscripts.

Natalia Gavrilova made an outreach lecture about biosocial survey research in the US at the international seminar "Contemporary Methods of Demographic Analysis" organized by the United Nations Population Fund (UNFPA) in Bishkek, Kyrgyzstan (November 3-7, 2008).  Participants were demographers and statisticians (including representatives of governmental organizations) from all five countries of Central Asia (Kazakhstan, Kyrgyzstan, Tadzhikistan, Turkmenistan and Uzbekistan).  This lecture prompted significant interest among participants.  Population-based biosocial survey research has not yet been carried out on a large scale in these countries.  Participants were also interested in contemporary methods of population health measurement and estimation of healthy life expectancy. 

In November, Stacy Lindau attended a meeting of the National Academies of Science National Research Council which is generating a report on Collecting, Storing, Protecting, and Accessing Biological Data Collected in Social Surveys in Washington, DC. In December, she also participated in a meeting on the Scientific Assessment of Biomeasures in the Panel Study of Income Dynamics in Ann Arbor, MI. 

News From the NEJM, Nature Journals, Science, BMJ and PNAS

Homo erectus Hips
Human pelvic morphology is central to the understanding of obstetrics, sexual dimorphism, and neonatal brain size and patterns of brain growth, as well as the evolution of body form ...

[Neuroscience] Brain vasopressin is an important regulator of maternal behavi...
The neuropeptide arginine vasopressin (AVP) is arguably among the most potent regulators of social behaviors in mammals identified to date....

[Neuroscience] Comparing face patch systems in macaques and humans
Face recognition is of central importance for primate social behavior. In both humans and macaques, the visual analysis of faces...

[Evolution] The quantitative genetics of sex differences in parenting 
Sex differences in parenting are common in species where both males and females provide care. Although there is a considerable...

EARLY RELEASE: Rosuvastatin to Prevent Vascular Events in Men and Women with ...
Background Increased levels of the inflammatory biomarker high-sensitivity C-reactive protein predict cardiovascular events. Since statins lower levels of high-sensitivity C-reactive protein as well as cholesterol, we hypothesized that people with ...

ORIGINAL ARTICLE: General and Abdominal Adiposity and Risk of Death in Europe
This study examined the association of body-mass index (BMI), waist circumference, and waist-to-hip ratio with the risk of death among more than 350,000 European subjects who had no major chronic diseases. The data suggest that both general and abdominal adiposity are associated with the risk of death and support the use of waist circumference or waist-to-hip ratio in addition to BMI for assessment of the risk of death, particularly among persons with a lower BMI.

EDITORIAL: Treating Low Sexual Desire -- New Findings for Testosterone in Women
Decreased or low sexual desire is commonly reported by women from late adolescence through the seventh decade across a number of cultures. Estimates of prevalence range from 25 to 53%.1,2,3 ...

ORIGINAL ARTICLE: Testosterone for Low Libido in Postmenopausal Women Not Tak... 
In this double-blind, placebo-controlled, 52-week trial among postmenopausal women not receiving estrogen therapy, treatment with a patch delivering 300 {micro}g of testosterone per day resulted in a significant although modest increase in the 4-week frequency of satisfying sexual episodes (1.4 more episodes per month), but the women were also subject to more adverse events, including androgenic side effects.

PERSPECTIVE: Screening for Prostate Cancer among Men 75 Years of Age or Older
Prostate-cancer screening with the prostate-specific antigen (PSA) test remains one of the most controversial issues in modern medicine. The U.S. Preventive Services Task Force (USPSTF), an independent group of experts ...

EDITORIAL: Elevated C-Reactive Protein in Atherosclerosis -- Chicken or Egg?
One of the most debated topics in cardiovascular medicine is whether C-reactive protein (CRP), a component of the acute-phase response, is a causal factor in the pathogenesis of atherosclerosis.1,2 If ...

REVIEW ARTICLE: Medical Progress: Uric Acid and Cardiovascular Risk
This review summarizes relevant studies concerning uric acid and possible links to hypertension, renal disease, and cardiovascular disease. Whether uric acid is an independent risk factor for such diseases is still a point of debate. Current evidence is presented.

EDITORIAL: Does It Matter How Hypertension Is Controlled?
Hypertension is one of the most important risk factors for cardiovascular and renal diseases. Currently, approximately 73 million adults in the United States and approximately 1 billion adults worldwide have ...


Biomarkers and Aging in the News Media

Periods of healthy old age 'vary'
The health of older people varies widely across Europe, even in those with longer life expectancies, a report claims.
'Love handles' risk early death
Carrying extra fat around your middle increases your risk of early death, even if your overall weight is normal, say researchers.
Some Obese Kids Have Middle-Aged Arteries
Obese children as young as 10 had the arteries of 45-year-olds and other heart abnormalities greatly increasing their risk of heart disease, say doctors who used ultrasound tests to take a peek inside.
Study: Vitamins Don't Thwart Heart Disease
Vitamins C and E do nothing to prevent heart disease in men, one of the largest and longest studies of these supplements has found. Vitamin E even appeared to raise the risk of bleeding strokes, a danger seen in an earlier study.
Migraines May Cut Breast Cancer Risk
Women who suffer from migraine headaches may be at significantly lower risk of developing breast cancer, a new study shows.
"Western" Diet Is A Global Heart Risk
A study shows that the risk of heart attack crosses geographic boundaries and correlates strongly to the so-called Western diet that favors salty snacks and fried foods, and to a lesser extent, meat.
Vitamin Didn't Lower Prostate Cancer Risk
A large government study of whether Vitamin E and selenium protect men against prostate cancer has been suspended, federal health officials announced yesterday, after an independent analysis determined that the nutrients did not reduce the risk for the common malignancy.
Sharp-witted elderly shed insight on dementia
People who can keep razor-sharp memory well into their 80s appear to have fewer fiber-like tangles of a protein linked with Alzheimer's than those who age normally, researchers said.
Saturated Fats, Intestinal Cancer Linked
If you eat a lot of saturated fat, you may be more at risk for cancer of the small intestine, according to a new study.
Potential New Biomarker Of Age-related Macular Degeneration Found
In its advanced stages, AMD destroys the detailed, central vision we need to read, drive, recognize faces, and enjoy daily life, and is a major cause of vision loss in the U.S. Ophthalmic researchers are making rapid progress in understanding how genetics, immune system factors, nutrition choices, and other variables interact to produce or prevent AMD.
Metabolic Syndrome? Nuts!
High-heart-risk older adults who add 2 tablespoons per day of mixed nuts to the Mediterranean diet can reverse their metabolic syndrome, even though they don't lose weight.
Attend Religious Services, Live Longer
Women who regularly attend religious services may reduce their risk of death by about 20 percent, according to a new study.
Having a Bad Boss Is Bad for the Heart
People who consider their bosses to be unfair, arbitrary, inconsiderate, and generally deficient in managerial skills are at greater risk for having a heart disease event such as a heart attack, a new Swedish study shows.
Activity, Sleep May Cut Cancer Risk
Physical activity may cut cancer risk, and sleeping at least 7 hours per night may maximize that benefit, new research shows.
More sex means less stress
Yoga? Yawn. Research shows a great way to ward off anxiety is by connecting in bed. Grab your partner and feel tension slip away.
Too Little Vitamin D Puts Heart at Risk
Getting too little vitamin D may be an underappreciated heart disease risk factor that's actually easy to fix, studies suggest.
Living In Multigenerational Households Triples Women's Heart Disease Risk
Living in a household with several generations of relatives triples a woman's risk of serious heart disease, suggests research published in the journal Heart.


NIH Press Releases

New Survey Suggests Growing Awareness of COPD, Nation's Fourth Leading Killer
Awareness of COPD (chronic obstructive pulmonary disease) is growing, but few Americans have a thorough understanding of the disease, according to a new national survey released today. The National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health analyzed results from the annual HealthStyles survey of American public health attitudes, knowledge, practices, and lifestyle habits, conducted each summer by Porter Novelli.
Statement from Elizabeth G. Nabel, M.D., Director, National Heart, Lung, and ...
Two studies supported by the National Heart, Lung, and Blood Institute (NHLBI) show that adding hsCRP levels to assess risk of a first heart attack or stroke in middle-aged or older adults improves accuracy over the traditional assessment tools by between 5 percent and 14 percent.
NEI Releases Complete Data from Age-Related Eye Disease Study
The National Institute on Drug Abuse (NIDA), part of the National Institutes of Health, will convene a one-day mini-convention at the Society for Neuroscience Annual Meeting in Washington, D.C.
New NIH Policy Establishes Goals to Support Scientists Early in Their Careers
The National Institutes of Health (NIH) announced today a new policy establishing goals to encourage funding for scientists new to NIH and those who are at an early stage in their careers.
According to a New Government Survey, 38 Percent of Adults and 12 Percent of ...
According to a New Government Survey, 38 Percent of Adults and 12 Percent of Children Use Complementary and Alternative Medicine
Review of Prostate Cancer Prevention Study Shows No Benefit for Use of Seleni...
Review of Prostate Cancer Prevention Study Shows No Benefit for Use of Selenium and Vitamin E Supplements
Variations in Gene Activity Can Predict the Survival of Patients with Lymphoma
Variations in Gene Activity Can Predict the Survival of Patients with Lymphoma



NIH Announcements


Replication and Fine-Mapping Studies for the Genes Environment and Health Initiative (GEI)(R01)
Using Systems Science Methodologies to Protect and Improve Population Health (R21)
Methodology and Measurement in the Behavioral and Social Sciences (R01)
Roybal Centers for Translational Research on Aging (P30)
Request for Applications from the NIH Guide for Grants and Contracts
Neural and Behavioral Profiles of Cognitive Aging (R01)
Request for Applications (RFA) Number: RFA-AG-09-010
Archiving and Development of Socialbehavioral Datasets in Aging Related Studies, (R03)
PAR-08-250
Translational Research at the Aging/Cancer Interface (TRACI) (R01)
Program Announcement: PA-08-230
Translating Basic Behavioral and Social Science Discoveries into Intervention...
Request for Applications from the NIH Guide for Grants and Contracts

Social Neuroscience of Aging (R01)
Request for Applications (RFA) Number: RFA-AG-09-006
Biomarkers of Infection-Associated Cancers (R01)
Program Announcement from the NIH Guide for Grants and Contracts
Biomarkers of Infection-Associated Cancers (R21)
Program Announcement from the NIH Guide for Grants and Contracts
Limited Competition: Renewal of Aging Intervention Testing Program (U01)
Request for Applications from the NIH Guide for Grants and Contracts
Biosocial Approaches to Infertility Research (R21)
Program Announcement from the NIH Guide for Grants and Contracts


Events


January 28-29, 2009.  The National Social Life Health and Aging Project (NSHAP) will host the *NSHAP Early Results Conference*, an NIA funded, competitive workshop to present findings on integrated health and aging research using the first wave of the NSHAP data.  Please contact Sara Leitsch at Leitsch-Sara@norc.org  for more information.

Population Association of America Annual Meeting. April 30-May 2, 2009. Detroit, Michigan Marriott Renaissance Center.

The 19th IAGG World Congress of Gerontology and Geriatrics. July 5-10, 2009. Paris, France

Gerontological Society of America Annual meeting will be held November 18-22, 2009 in Hilton and Marriott Marquis, Atlanta, GA

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This Newsletter  is supported by a grant from the National Institute on Aging, National Institutes of Health (Grant No. 5 P30 AG012857)

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