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CCBAR Newsletter – November, 2010

Editors:  Natalia Gavrilova and Stacy Tessler Lindau



Study of sexuality at older ages by Lindau and Gavrilova (BMJ, 2010) was recently featured by "Aging News" - a Newsletter of the Institute on Aging at the University of Wisconsin-Madison. Full text of the article can be found here.

CCBAR member, Dr. Natalia Gavrilova, participated in the annual meeting of the Gerontological Society of America
held in New Orleans. Of particular interest were conference symposiums "Followed to Extinction: Predictors of Exceptional Survival in Very Long Term Cohort Studies," (Chairs - David Meltzer and Jack Guralnik), "Measuring and Understanding Reserve and Resiliance" (Chair - Thomas Perls) and "Cross-National Conversations on Healthy Aging and Longevity with One Who Arrived: a 104-Old Japanese Physician" (Chair - Leonard Poon).  These symposiums discussed predictors of exceptional longevity in a variety of long-term population studies.

News from the NEJM, Nature Journals, Science, BMJ, PNAS and JAMA

Grants: Funding crisis hits US ageing research
Shortfalls hamper scientists' efforts to address a predicted epidemic of age-related diseases.
Cancer: Metabolic link to breast cancer
A protein that senses a cell's metabolic state may serve as a 'switch' to allow breast cancer to develop. This could be a molecular reason for why a high intake of calories and weight gain are strong risk factors for breast cancer.Kevin Gardner of
Evolution: Neanderthals matured fast
Analysis of fossil teeth from ancient humans and Neanderthals suggests that Neanderthals grew and matured more rapidly than Homo sapiens. This finding helps to pin down an evolutionary origin for humans' prolonged childhood and adolescence, which may have provided an evolutionary advantage.Tanya Smi...
Early detection of aging cartilage and osteoarthritis in mice and patient sam...
Evolutionary history of partible paternity in lowland South America [Anthropo...
Partible paternity, the conception belief that more than one man can contribute to the formation of a fetus, is common in lowland South America and characterized by nonexclusive mating relationships and various institutionalized forms of recognition and investment by multiple cofathers. Previous wor...
SIRT1: recent lessons from mouse models
The family of protein deacetylases represented by yeast Sir2 has been the focus of intense investigation because of the longevity activity of Sir2 in yeast, worms and flies. Research in mammals has mainly focused on SIRT1, the closest homologue of Sir2. Emerging evidence from mouse

Cancer biology: Cell neighbours aid cancer relapse
Cancer patients often relapse after seemingly successful chemotherapy
- perhaps because cellular stress responses to the drugs shield some cancer cells, creating a protected reservoir that can seed fresh tumour growth.Luke Gilbert and Michael Hemann at the Massachusetts Institute of Technology in Ca...
Resilience to social stress coincides with functional DNA methylation of the ...
Corticotrophin releasing factor (CRF) and its receptors are involved in the neuroendocrine and behavioral responses to stress. Here, Elliot and colleagues describe alterations in DNA methylation of the Crf gene that regulate its expression and show that these alterations correlate with resilience to...
DDS, 4,4'-diaminodiphenylsulfone, extends organismic lifespan [Cell_Biology]
DDS, 4,4'-diaminodiphenylsulfone, is the most common drug prescribed to treat Hansen disease patients. In addition to its antibacterial activity, DDS has been reported to be involved in other cellular processes that occur in eukaryotic cells. Because DDS treatment significantly enhances the antioxid...
Late-Onset Hypogonadism in Middle-Aged and Elderly Men
Are CSF Biomarkers Ready for Prime Time as Diagnostics for Alzheimer Disease?...
Association of Features of Primary Health Care With Coronary Heart Disease Mo...
Context  The goal of US health care reform is to extend access. In England, with a universal access health system, coronary heart disease (CHD) mortality rates have decreased by more than two-fifths in the last decade, but variations in rates between local populations persist.
Optimal Cardiovascular Prevention Strategies for the 21st Century [Commentary]
Docosahexaenoic Acid Supplementation and Cognitive Decline in Alzheimer Disea...
Context  Docosahexaenoic acid (DHA) is the most abundant long-chain polyunsaturated fatty acid in the brain. Epidemiological studies suggest that consumption of DHA is associated with a reduced incidence of Alzheimer disease. Animal studies demonstrate that oral intake of DHA reduces Alzheimer-...
Maximizing the Potential of an Aging Population [Commentary]
Coronary artery disease: Diagnostic blood test validated
A blood-based gene expression test developed to aid in the diagnosis of coronary artery disease (CAD) has now been prospectively validated in the multicenter PREDICT trial. According to Dr Eric Topol, one of the PREDICT investigators, ?the test, which is commercially available, can be used
The relationship between blood pressure and cognitive function
The relationship between blood pressure (BP) and cognitive outcomes in elderly adults has implications for global health care. Both hypertension and hypotension affect brain perfusion and worsen cognitive outcomes. The presence of hypertension and other vascular risk factors has been associated with...
Biomarkers: Salivary cortisol or cortisone?
Measurement of salivary cortisol is used in the diagnosis of hypercortisolism and hypocortisolism. A new study by Perogamvros et al. suggests that measuring salivary cortisone, the inactive metabolite of cortisol, may be clinically useful under certain circumstances. But does analysis of salivary c...
Reproductive endocrinology: Postmenopausal hormone therapy: risks versus bene...
The Endocrine Society's recent Scientific Statement on postmenopausal hormone therapy highlights the dangers of calculating risks and benefits associated with hormone therapy for women in early menopause on the basis of evidence from previous studies. But does it provide a quantum shift in the clini...
Pleasurable behaviors reduce stress via brain reward pathways [Neuroscience]
Individuals often eat calorically dense, highly palatable "comfort" foods during stress for stress relief. This article demonstrates that palatable food intake (limited intake of sucrose drink) reduces neuroendocrine, cardiovascular, and behavioral responses to stress in rats. Artificially sweetened...
Impact of the human circadian system, exercise, and their interaction on card...
The risk of adverse cardiovascular events peaks in the morning (9:00 AM) with a secondary peak in the evening (8:00 PM) and a trough at night. This pattern is generally believed to be caused by the day/night distribution of behavioral triggers, but it is unknown whether the endogenous circadian syst...
Association of Adolescent Obesity With Risk of Severe Obesity in Adulthood [O...
Context  Although the prevalence of obesity has increased in recent years, individuals who are obese early in life have not been studied over time to determine whether they develop severe obesity in adulthood, thus limiting effective interventions to reduce severe obesity incidence and its pote...

Biomarkers and Aging in the News Media

Job strain 'puts women at risk'
Women with high job strain have a 40% increased risk of cardiovascular disease compared with those in less demanding posts, a study suggests.
Bereavement 'raises heart risk'
The death of a spouse or child can cause elevated heart rate and other potentially harmful heart rhythm changes among the recently bereaved, a study finds.
Study: Kids of deployed military have more behavioral problems
A new study suggests nine years of war is taking a toll on U.S. children.
Binge drinking could hurt teens later in life
Binge drinking during adolescence may permanently disrupt a person's stress hormones, leading to mental disorders in adulthood, based on new research on rats.
Money is big issue in stress survey
More Americans are worried about money than in the past few years, and the stress is taking a physical toll, finds an annual survey.
Many Sleep-Deprived Americans Blame Stress
Millions of Americans say they're not getting enough sleep and that the lack of shut-eye affects their personal relationships, job performance, and mental and physical health, according to a new study.
Early wrinkles no sign of an early grave, study says
Early wrinkles, premature balding and gray hairs before you feel middle-aged can be distressing signs of time's relentless march. But looking older than you really are doesn't necessarily signal an early death, found a new study.
Alzheimer's disease inherited through maternal line, study finds
A family history of Alzheimer's disease significantly increases the risk for developing this disorder, but a new study suggests that which of your parents has the disease is very important.
Chocolate eaters may have healthier hearts: study
Older women who eat more chocolate are less likely to develop heart problems over a nearly 10-year-period, new study findings report.
Vitamin D deficit doubles risk of stroke in whites, but not in blacks, study ...
Low levels of vitamin D, the essential nutrient obtained from milk, fortified cereals and exposure to sunlight, doubles the risk of stroke in whites, but not in blacks, according to a new study.
Soy isoflavones may modify risk of breast cancer
Increased phytoestrogens commonly found in dietary soy may modify the risk of some types of breast cancer, according to new findings.
Study Ties Ovarian Cancer and Hormone Therapy
More bad news about post-menopausal hormone therapy: a new European study reports that women who take hormones are at significantly increased risk for this cancer.
Sex hormones 'make brain younger'
Tests on post-menopausal women on HRT suggest the sex hormones can make the brain function more like that of a younger woman.
DHA improves memory and cognitive function in older adults, study suggests
Taking docosahexaenoic acid may improve memory and learning in older adults with mild cognitive impairments. This is promising news for many aging Americans who are searching for options to maintain memory and support overall cognitive health.
Gene Screening vs. Family History: Which Wins?
Researchers led by Dr. Charis Eng, chairman and founding director of the Genomic Medicine Institute of the Cleveland Clinic, found that a thorough family history better predicted the risk for developing certain cancers than genomic screening did.
Silent vascular disease accompanies cognitive decline in healthy aging
Older people who are leading active, healthy lifestyles often have silent vascular disease that can be seen on brain scans that affect their ability to think, according to a new study.
Budget cut fears for elderly care
A number of councils fear budget pressures will hit care services which help elderly people and adults with disabilities live independently, a BBC survey finds.
As boomers age, 1 in 5 drivers will be oldsters
Baby boomers who first danced to that 1964 pop hit about a granny burning up the road in her hot rod will begin turning 65 in January. Experts say keeping those drivers safe and mobile is a challenge with profound implications.
Kids of divorce have double the risk of stroke
Children whose parents divorce are more than twice as likely to suffer a stroke at some point during their lives than other children, according to a new study.
New insight into the cause of common dementia
Researchers have found a clue as to how some people develop a form of dementia that affects the brain areas associated with personality, behavior and language.
Understanding aging by studying reproduction
Do examples of rejuvenation exist in nature? Yes, during reproduction! For the first time, scientists have managed to visualize, in the model organism C. elegans, the sudden 'rejuvenation' of oocytes just before fertilization. This work opens new avenues for understanding aging and the diseases that are associated with it.

NIH Press Releases

NIH adds first images to major research database
The National Institutes of Health has expanded a genetic and clinical research database to give researchers access to the first digital study images. The National Eye Institute (NEI), in collaboration with the National Center for Biotechnology Information (NCBI), has made available more than 72,000 lens photographs and fundus photographs of the back of the eye, collected from the participants of the Age-Related Eye Disease Study (AREDS).
Very low birthweight Down syndrome infants at high risk for heart, lung disor...
Very low birthweight Down syndrome infants are at higher risk for disorders of the heart and lungs than are very low birthweight infants who do not have a chromosomal variation, according to a study by a National Institutes of Health research network.
Daily hemodialysis helps protect kidney patients' hearts
Frequent hemodialysis improved left ventricular mass (heart size) and self-reported physical health compared to conventional hemodialysis for kidney failure, according to the Frequent Hemodialysis Network (FHN) Daily Trial funded by the National Institutes of Health and the Centers for Medicare & Medicaid Services. Results were published online Nov. 20, 2010, in the New England Journal of Medicine to coincide with a presentation at the American Society of Nephrology meeting in Denver.
Mouse study shows effect of blood pressure drug on Alzheimer's disease
A drug used decades ago to treat high blood pressure has been shown to improve learning and memory in mouse models of Alzheimer's disease, according to a new study by researchers at the National Institute on Aging (NIA), part of the National Institutes of Health. The study found that the drug, diazoxide, acted on nerve cells in the mouse brain in ways that slowed the development of the neurodegenerative disorder. The findings appear in the Nov. 15, 2010, print edition of the Journal of Alzheimer's Disease.
Lung cancer trial results show mortality benefit with low-dose CT
The National Cancer Institute (NCI) is today releasing initial results from a large-scale test of screening methods to reduce deaths from lung cancer by detecting cancers at relatively early stages.
NIH researchers identify genetic elements influencing the risk of type 2 diab...
A team led by researchers at the National Human Genome Research Institute (NHGRI), part of the National Institutes of Health, has captured the most comprehensive snapshot to date of DNA regions that regulate genes in human pancreatic islet cells, a subset of which produces insulin.
1000 Genomes Project publishes analysis of completed pilot phase
Small genetic differences between individuals help explain why some people have a higher risk than others for developing illnesses such as diabetes or cancer. Today in the journal Nature, the 1000 Genomes Project, an international public-private consortium, published the most comprehensive map of these genetic differences, called variations, estimated to contain approximately 95 percent of the genetic variation of any person on Earth.


NIH Announcements

The Market for Long-Term Care Insurance (R01)
Funding Opportunity RFA-RM-11-002 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) solicits research (R01) applications from institutions/organizations proposing to advance knowledge on the economics of long-term care (LTC), including topics related to private and public LTC insurance, the Community Living Assistance Services and Supports (CLASS) program, and related topics. The FOA is a component of the Common Fund initiative on Health Economics for Health Care Reform (
NIH Basic Behavioral and Social Science Opportunity Network (OppNet) Short-te...
Funding Opportunity RFA-DE-11-003 from the NIH Guide for Grants and Contracts. This NIH Funding Opportunity Announcement (FOA), issued by the NIH Basic Behavioral and Social Science Opportunity Network [OppNet] solicits applications for short-term mentored career development (K18) awards in the basic behavioral and social sciences research (b-BSSR) from three months to one year in duration.
Correction to RFA-CA-10-017, Scientific Meetings for Creating Interdisciplinary Research Teams in Basic Behavioral and Social Science Research (R13), in Order to Simplify Submission Requirements
Limited Competition: Fogarty International Research Collaboration - Behavioral and Social Sciences (FIRCA-BSS) Research Award (R03)
New Time Limit for NIH Resubmission Applications
National Institute on Aging: Revision Requests for Active Program Projects (P01)

Program Announcement from the NIH Guide for Grants and Contracts
NIH Basic Behavioral and Social Science Opportunity Network (OppNet) Short-term Interdisciplinary Research Education Program for New Investigators (R25)
Request for Applications (RFA) Number: RFA-NR-11-002
Expiration Date: January 7, 2011
Scientific Meetings for Creating Interdisciplinary Research Teams in Basic Behavioral and Social Science Research (R13)
Psychosocial Stress and Behavior: Integration of Behavioral and Physiological...
Request for Applications from the NIH Guide for Grants and Contracts
Development of Comprehensive and Conceptually-based Measures of Psychosocial ...
Request for Applications from the NIH Guide for Grants and Contracts
Basic Mechanisms Influencing Behavioral Maintenance (R01)
Request for Applications from the NIH Guide for Grants and Contracts
Chronic, Non-Communicable Diseases and Disorders Across the Lifespan: Fogarty...
Program Announcement from the NIH Guide for Grants and Contracts
Participation of NIGMS on PAR-10-235, Climate Change and Health: Assessing an...
Effects of the Social Environment on Health: Measurement, Methods and Mechani...
Request for Applications from the NIH Guide for Grants and Contracts



4th National Conference on Genomics and Public Health: Using Genomic Information to Improve Health Now and in the Future.
Date: Wednesday, December 8 - Friday, December 10, 2010. Location: Bethesda North Marriott in Bethesda, Maryland

Population Association of America Annual Meeting.
The 2011 Annual Meeting will be held March 31-April 2 at the Marriott Wardman Hotel, Washington, DC.
(Note:  The Welcome Mixer is on Wednesday, March 30, 8:30 p.m.)

2011 American Geriatrics Society Annual Meeting, May 11-14, 2011. Gaylord National Resort and Convention Center, National Harbor, MD.

23rd meeting of REVES will be held in Paris France, from May 25 to 27, 2011

This Newsletter  is supported by a grant from the National Institute on Aging, National Institutes of Health (Grant No. 5 P30 AG012857)

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